January 12, 2020
We are pleased that Novartis chose to partner with ClinBAY for the development of the ggPMX R package.
ggPMX is an open-source R package freely available on CRAN since April 2019. It generates standard diagnostic plots for mixed effect models used in pharmacometric activities.
The package builds on the R-package ggplot2 and aims at providing a workflow that is consistent, reproducible and efficient, resulting in high quality graphics ready-to-use in submission documents and publications. Intuitive functions and options allow for optimal figure customization and graphics stratification. ggPMX enables straightforward generation of PDF, Word or PNG output files that contain all diagnostic plots for keeping track of modeling results. The package is currently compatible with Monolix versions 2016 and later, and nlmixr outputs as well.
Using simple function calls, the toolbox can produce different model diagnostic plots (e.g. residual and EBE-based plots assessing possible trends and the shape of the distributions such as IWRES vs IPRED, VPCs, observations vs predictions, etc.).
In addition, shrinkage and summary parameters tables can be also produced. By default, the PDF- or Word-format diagnostic report contains essential goodness-of-fit plots. However, these can be adapted to produce different sets of diagnostics as desired by the user, and any of the plots may be customized individually. The types of supported customizations include modifications of the graphical parameters, labels, and various stratifications by covariates.
ClinBAY provides a strong expertise in development and validation of software for the pharmaceutical industry. Some of the software that we have developed and that you can download for free are:
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