Publications
Articles
Patient Perspectives on Irritable Bowel Syndrome
28 Jul 2025
Articles
Patient Perspectives on Irritable Bowel Syndrome
28 Jul 2025
Articles
Διαφορές ανάμεσα στα τρία προτεινόμενα εμβόλια για τον ιό COVID-19
Δεκέμβριος 17, 2020
Articles
Διαφορές ανάμεσα στα τρία προτεινόμενα εμβόλια για τον ιό COVID-19
Δεκέμβριος 17, 2020
Articles
Differences between the three candidate COVID-19 vaccines
December 17, 2020
Articles
Differences between the three candidate COVID-19 vaccines
December 17, 2020
Articles
Using SQL for cross-platform statistical programming (for SAS, R and more)
03 December 2020
Articles
Using SQL for cross-platform statistical programming (for SAS, R and more)
03 December 2020
Articles
Innovative prolonged‑release oral alkalising formulation allowing sustained urine pH increase
Innovative prolonged‑release oral alkalising formulation allowing sustained urine pH increase with twice daily administration: randomised trial in healthy adults
15 September 2020
Articles
Innovative prolonged‑release oral alkalising formulation allowing sustained urine pH increase
15 September 2020
Innovative prolonged‑release oral alkalising formulation allowing sustained urine pH increase with twice daily administration: randomised trial in healthy adults
Articles
Efficacy and safety of an innovative prolonged-release combination drug in patients with distal renal tubular acidosis: an open-label comparative trial versus standard of care treatments
Distal renal tubular acidosis (dRTA), due to impaired acid secretion in the urine, can lead to severe long-term consequences. Standard of care (SoC) oral alkalizers, requiring several daily intakes, are currently used to restore normal plasma bicarbonate levels. A new prolonged-release formulation, ADV7103, has been developed to achieve a sustained effect with an improved dosing scheme.
26 July 2020
Articles
Efficacy and safety of an innovative prolonged-release combination drug in patients with distal renal tubular acidosis: an open-label comparative trial versus standard of care treatments
26 July 2020
Distal renal tubular acidosis (dRTA), due to impaired acid secretion in the urine, can lead to severe long-term consequences. Standard of care (SoC) oral alkalizers, requiring several daily intakes, are currently used to restore normal plasma bicarbonate levels. A new prolonged-release formulation, ADV7103, has been developed to achieve a sustained effect with an improved dosing scheme.
Articles
Hydroxychloroquine and short-course radiotherapy in elderly patients with newly diagnosed high-grade glioma: a randomized phase II trial
Effective treatment for patients at least 70 years with newly diagnosed glioblastoma remains challenging and alternatives to conventional cytotoxics are appealing. Autophagy inhibition has shown promising efficacy and safety in small studies of glioblastoma and other cancers. We conducted a randomized phase II trial to compare radiotherapy with or without hydroxychloroquine (2:1 allocation).
27 April 2020
Articles
Hydroxychloroquine and short-course radiotherapy in elderly patients with newly diagnosed high-grade glioma: a randomized phase II trial
27 April 2020
Effective treatment for patients at least 70 years with newly diagnosed glioblastoma remains challenging and alternatives to conventional cytotoxics are appealing. Autophagy inhibition has shown promising efficacy and safety in small studies of glioblastoma and other cancers. We conducted a randomized phase II trial to compare radiotherapy with or without hydroxychloroquine (2:1 allocation).
Articles
The Effect of Carryover in the Estimation of Model Adjusted Means in Cross-Over Studies
Carryover effects constitute a potential issue when using the crossover design. Multiple methods exist, both for modelling the carryover effect, and predicting adjusted means from these models. In this paper, we investigated the reliability of the prediction methods for estimating the model adjusted means and their differences, using a simulation study.
March 2020
Articles
The Effect of Carryover in the Estimation of Model Adjusted Means in Cross-Over Studies
March 2020
Carryover effects constitute a potential issue when using the crossover design. Multiple methods exist, both for modelling the carryover effect, and predicting adjusted means from these models. In this paper, we investigated the reliability of the prediction methods for estimating the model adjusted means and their differences, using a simulation study.
Articles
Executing R from SAS
Statistical reporting primarily performed using SAS, wanted to execute an analysis only available currently in R
05 March 2020
Articles
Executing R from SAS
05 March 2020
Statistical reporting primarily performed using SAS, wanted to execute an analysis only available currently in R
Articles
Evaluating the Potential of Drug Combinations
14 January 2020
Articles
Evaluating the Potential of Drug Combinations
14 January 2020
Articles
Insulin exposure mitigates the increase of arterial stifness in patients with type 2 diabetes and albuminuria: an exploratory analysis
Acta Diabetologica, pp1-7
16 April 2019
Articles
Insulin exposure mitigates the increase of arterial stifness in patients with type 2 diabetes and albuminuria: an exploratory analysis
16 April 2019
Acta Diabetologica, pp1-7
Articles
A free tool to generate automatically user documentation for SAS macro libraries
PhUSE EU Connect 2018, Frankfurt, Germany
November 2018
Articles
A free tool to generate automatically user documentation for SAS macro libraries
November 2018
PhUSE EU Connect 2018, Frankfurt, Germany
Articles
Bayesian adaptive designs in single ascending dose trials in healthy volunteers 2015
April 16 2015
Articles
Bayesian adaptive designs in single ascending dose trials in healthy volunteers 2015
April 16 2015
Posters
Bayesian adaptive designs for phase 1 studies in healthy volunteers
Symposium on early phase dose finding methodology.
April 14-17 2015
Posters
Bayesian adaptive designs for phase 1 studies in healthy volunteers
April 14-17 2015
Symposium on early phase dose finding methodology.
Articles
Bayesian adaptive designs in single ascending dose trials in healthy volunteers 2014
Br J Clin Pharmacol. doi: 10.1111/bcp.12344
February 17 2014
Articles
Bayesian adaptive designs in single ascending dose trials in healthy volunteers 2014
February 17 2014
Br J Clin Pharmacol. doi: 10.1111/bcp.12344
Articles
Long term inhibition of IL-17A with secukinumab reduces spinal inflammation but has no influence on fatty lesions as assessed by magnetic resonance imaging in patients with ankylosing spondylitis
EULAR 2013 congress, Madrid, Spain.
June 12-15 2013
Articles
Long term inhibition of IL-17A with secukinumab reduces spinal inflammation but has no influence on fatty lesions as assessed by magnetic resonance imaging in patients with ankylosing spondylitis
June 12-15 2013
EULAR 2013 congress, Madrid, Spain.
Articles
Using Bonferroni, BIC and AIC to assess evidence for alternative biological pathways: covariate selection for the multilevel Embryo-Uterus model
BMC Med Res Methodol. 13:73. doi: 10.1186/1471-2288-13-73
June 6 2013
Articles
Using Bonferroni, BIC and AIC to assess evidence for alternative biological pathways: covariate selection for the multilevel Embryo-Uterus model
June 6 2013
BMC Med Res Methodol. 13:73. doi: 10.1186/1471-2288-13-73
Posters
Statistical evaluation of QT/QTc prolongation and proarrhythmic potential for non-antiarrhythmic drugs
36th Annual Conference of PSI. Glasgow, UK.
13-15 May 2013
Posters
Statistical evaluation of QT/QTc prolongation and proarrhythmic potential for non-antiarrhythmic drugs
13-15 May 2013
36th Annual Conference of PSI. Glasgow, UK.
Presentations
Application of Bayesian Statistics in early development studies
Club Phase I, Nice Sophia Antipolis, France.
April 11-12 2013
Presentations
Application of Bayesian Statistics in early development studies
April 11-12 2013
Club Phase I, Nice Sophia Antipolis, France.
Presentations
Assessment of Brain Kappa Opioid Receptor Occupancy after Single Oral Doses of LY2456302 as Measured by PET with the Radioligand LY2879788 in Healthy Subjects
American College of Neuropsychopharmacology, 51st annual meeting, Hollywood, USA.
December 2-6 2012
Presentations
Assessment of Brain Kappa Opioid Receptor Occupancy after Single Oral Doses of LY2456302 as Measured by PET with the Radioligand LY2879788 in Healthy Subjects
December 2-6 2012
American College of Neuropsychopharmacology, 51st annual meeting, Hollywood, USA.
Articles
The intramammary efficacy of first generation cephalosporins against Staphylococcus aureus mastitis in mice
Vet Microbiol. 2012 160(1-2):141-50.
November 9 2012
Articles
The intramammary efficacy of first generation cephalosporins against Staphylococcus aureus mastitis in mice
November 9 2012
Vet Microbiol. 2012 160(1-2):141-50.
Presentations
SAS macro package to automate coding graphs with ClinXport
PhUSE Conference 2012, Budapest, Hungary.
October 14-17 2012
Presentations
SAS macro package to automate coding graphs with ClinXport
October 14-17 2012
PhUSE Conference 2012, Budapest, Hungary.
Presentations
Using a free syntax-colored SAS Log Viewer to bookmark important messages, filter them, and more!
PhUSE Conference 2012, Budapest, Hungary.
October 14-17 2012
Presentations
Using a free syntax-colored SAS Log Viewer to bookmark important messages, filter them, and more!
October 14-17 2012
PhUSE Conference 2012, Budapest, Hungary.
Presentations
Automation of clinical trial reporting: from shells to TFL outputs without a single line of SAS® code
FDA/PhUSE Annual Computational Science Symposium, Silver Spring Civic Center, Silver Spring, MD.
March 19-20 2012
Presentations
Automation of clinical trial reporting: from shells to TFL outputs without a single line of SAS® code
March 19-20 2012
FDA/PhUSE Annual Computational Science Symposium, Silver Spring Civic Center, Silver Spring, MD.
Presentations
Nouveaux designs, approche Bayésienne en phase précoce
Journée du Club Phase 1, Paris, France.
February 2 2012
Presentations
Nouveaux designs, approche Bayésienne en phase précoce
February 2 2012
Journée du Club Phase 1, Paris, France.
Articles
ClinXPORT: a software to streamline the analysis and reporting of clinical trials with SAS®
Phuse 2011, Brighton, UK.
October 10-12 2011
Articles
ClinXPORT: a software to streamline the analysis and reporting of clinical trials with SAS®
October 10-12 2011
Phuse 2011, Brighton, UK.
Presentations
ClinXPORT a software to streamline the analysis and reporting of clinical trials with SAS®
Phuse 2011, Brighton, UK.
October 10-12 2011
Presentations
ClinXPORT a software to streamline the analysis and reporting of clinical trials with SAS®
October 10-12 2011
Phuse 2011, Brighton, UK.
Articles
The effects of a single dose administration of SAM-531, a 5-HT6 antagonist, on sleep electroencephalogram (EEG) and quantitative wake EEG (qEEG) in healthy subjects
Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association 2010 July Volume 6, Issue 4, Supplement , Page S510.
July 2010
Articles
The effects of a single dose administration of SAM-531, a 5-HT6 antagonist, on sleep electroencephalogram (EEG) and quantitative wake EEG (qEEG) in healthy subjects
July 2010
Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association 2010 July Volume 6, Issue 4, Supplement , Page S510.
Articles
An open-label, positron emission tomography study to assess adenosine A2A brain receptor occupancy of vipadenant (BIIB014) at steady-state levels in healthy male volunteers
Clin Neuropharmacol 33(2):55-60
April-March 2010
Articles
An open-label, positron emission tomography study to assess adenosine A2A brain receptor occupancy of vipadenant (BIIB014) at steady-state levels in healthy male volunteers
April-March 2010
Clin Neuropharmacol 33(2):55-60
Articles
Development of the 2nd Generation Neurokinin-1 Antagonist LY686017 for Social Anxiety Disorder
Eur. Neuropsychopharmacol 20(2):80-7.
February 2010
Articles
Development of the 2nd Generation Neurokinin-1 Antagonist LY686017 for Social Anxiety Disorder
February 2010
Eur. Neuropsychopharmacol 20(2):80-7.
Articles
Pharmacokinetic parameters estimation using adaptive Bayesian P-splines models
Pharm Stat. 8(2):98-112.
April-June 2009
Articles
Pharmacokinetic parameters estimation using adaptive Bayesian P-splines models
April-June 2009
Pharm Stat. 8(2):98-112.
Presentations
Adaptive designs in clinical trials
UCL.
March 3 2009
Presentations
Adaptive designs in clinical trials
March 3 2009
UCL.
Posters
Bayesian dose selection strategy in biomarker trials
Bayesian Biostatistics Conference: Houston, Texas.
January 26-28 2009
Posters
Bayesian dose selection strategy in biomarker trials
January 26-28 2009
Bayesian Biostatistics Conference: Houston, Texas.
Presentations
Adaptive Bayesian Methods for Biomarker Trials: Application to Brain Imaging
PSI Biomarker in Early Phase, London, UK
November 18 2008
Presentations
Adaptive Bayesian Methods for Biomarker Trials: Application to Brain Imaging
November 18 2008
PSI Biomarker in Early Phase, London, UK
Articles
Decimaker: A statistical software using R, Microsoft .NET, R (D)COM Server and graphical libraries
PhUSE Paper AD05. Manchester, UK.
October 12-15 2008
Articles
Decimaker: A statistical software using R, Microsoft .NET, R (D)COM Server and graphical libraries
October 12-15 2008
PhUSE Paper AD05. Manchester, UK.
Articles
Bayesian hierarchical modeling of receptor occupancy in PET trials
J Biopharm Stat. 18 (2):256-72.
2008
Articles
Bayesian hierarchical modeling of receptor occupancy in PET trials
2008
J Biopharm Stat. 18 (2):256-72.
Presentations
Decimaker: software for adaptive design and Bayesian decision analysis
SMi adaptive design conference, London, UK.
February 6-7 2008
Presentations
Decimaker: software for adaptive design and Bayesian decision analysis
February 6-7 2008
SMi adaptive design conference, London, UK.
Presentations
Decimaker: software for adaptive design and Bayesian decision analysis
Bayesian Biostatistics conference, Houston, TX, USA.
January 30 - February 1 2008
Presentations
Decimaker: software for adaptive design and Bayesian decision analysis
January 30 - February 1 2008
Bayesian Biostatistics conference, Houston, TX, USA.
Articles
Imaging the norepinephrine transporter with positron emission tomography:initial human studies with (S,S)-[18F]FMeNER-D2
European Journal of Nuclear Medicine and Molecular Imaging 35(1):153-7
January 2008
Articles
Imaging the norepinephrine transporter with positron emission tomography:initial human studies with (S,S)-[18F]FMeNER-D2
January 2008
European Journal of Nuclear Medicine and Molecular Imaging 35(1):153-7
Articles
Joint detection of influential biomarkers and optimal dose-response model using penalties
Statistics in Medicine 26(27):4876-88.
November 30 2007
Articles
Joint detection of influential biomarkers and optimal dose-response model using penalties
November 30 2007
Statistics in Medicine 26(27):4876-88.
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